AERD is linked to atherosclerosis. Atherosclerosis is a common disorder of the arteries. It occurs when fat, cholesterol, and other substances build up in the walls of arteries and form a hard substance called plaque.
In AERD, cholesterol crystals break off from the plaque lining the arteries. These crystals move into the bloodstream. Once in circulation, the crystals get stuck in tiny blood vessels called arterioles. There, they reduce blood flow to tissues and cause swelling (inflammation) and tissue damage that can harm the kidneys or other parts of the body
The kidneys are involved about half of the time. Other body parts that may be involved include the skin, eyes, muscles and bones, brain and nerves, and organs in the abdomen. Acute kidney failure is possible if the blockages of the kidney blood vessels are severe.
Atherosclerosis of the aorta is the most common cause of AERD. The cholesterol crystals may also break off during aortic angiography, cardiac catheterization or surgery of the aorta or other major arteries.
In some cases, AERD may occur without a known cause.
The risk factors for AERD are the same as risk factors for atherosclerosis, including age, male gender, cigarette smoking, high blood pressure, and diabetes.
AERD may not cause any symptoms. If there are symptoms, they may begin suddenly, or slowly get worse over weeks or even months. Symptoms may include:
The doctor will perform a physical exam. Swelling can start in the legs, but may affect the whole body. An eye exam may show particles in the small arteries of the retina.
The doctor will listen to your lungs, heart, and large blood vessels with a stethoscope. Abnormal sounds may be heard. For example, a loud whooshing sound called a bruit may be heard over the aorta or renal artery.
Blood pressure may be high. There may be many ulcers on the skin of the lower feet.
Kanso AA, Hassan NMA, Badr KF. Microvascular and macrovascular diseases of the kidney. In: Brenner BM, ed. Brenner and Rector's The Kidney. 8th ed. Philadelphia, Pa; Saunders Elsevier; 2007:chap 32.
David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Herbert Y Lin, MD, PhD, Nephrologist, Massachusetts General Hospital; Associate Professor of Medicine, Harvard Medical School. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.